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130 Overexpression of dickkopf-related protein-1, one of the Wnt antagonists, ameliorated the severity of OA in mice by inactivation of the Wnt/-catenin signaling in subchondral bone

Cysteine Cysteine is a sulphur-containing amino acid that plays a crucial role in the structure of proteins and the production of antioxidants

Open field test (OFT) Each mouse was placed in an acrylic open-field arena (43 43 43 cm) virtually divided into peripheral and central zones (15 15 cm) for 15 min

Therefore, inactivation or inhibition of the enzyme GPX4 triggers overwhelming lipid peroxidation that causes iron-dependent cell death

This method repurposes PDB as a potential senolytic therapy in age-related disorders but also in cancer senescent cells elimination