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Tirzepatide The most common tirzepatide side effects include the following: Nausea Vomiting Diarrhea Belching or burping Stomach area pain Constipation Gastroesophageal reflux disease Heartburn Poor appetite Headache Fatigue Injection site reactions Pancreatitis Allergic reactions Hair loss Ozempic side effects The most common side effects in people using Ozempic were: Nausea Diarrhea Vomiting Constipation Heartburn Stomach area pain Poor appetite Headache Fatigue Injection site reactions Risk of thyroid tumors Pancreatitis Comparison of Tirzepatide and Ozempic When comparing tirzepatide vs