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Funding This paper was supported by San Matteo Hospital Foundation, Internal Medicine research fundings, PRIN2017. Publishers note All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Copper serves as a cofactor for lysyl oxidase and lysyl hydroxylase, enzymes essential for collagen cross-linking and structural integrity

ELISA assay for DNA fragmentation DNA fragmentation was quantified using a commercially available ELISA kit from Roche (Indianapolis, IN) in accordance with the manufacturers instructions

The crop yield component and productivity significantly declined due to Pb toxicity in different rice genotypes [21], where yield reduction was 46.27% to 69.12%

vitamin B12 has to be consumed through food Vitamin B 12 is concentrated in animal tissues, hence, vitamin B 12 is