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32,43 Moreover, because of the heterogeneous nature of tumors, there are considerable variations in NADPH-related processes in different tumors, for example, the main pathways of glutamine metabolism in the context of PDAC are different from the previous prevailing view as informed by studies of other cancers, 159,192 indicating the need for careful analyses of individual characteristics among cancers for establishing individualized precision therapy

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Oxidative Stress and Damage: A Vital Pathogenic Mechanism of CIPN It is well established that the production of reactive oxygen species (ROS) by antineoplastic agents induces apoptosis in cancer cells [14]