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IGF-1 binds to the IGF-1 receptor (IGF1R) IGF-1 can be used in embryonic stem cell (ESC) and mesenchymal stem cell (MSC) cultures to promote proliferation, as a replacement to insulin
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Diabetologia 46(12):1707 Chen J, Huang Y, Liu C et al (2023) The role of C-peptide in diabetes and its complications: an updated review
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Cell morphology shifts toward more cuboidal shapes, indicating increased stemness and restored proliferative potential
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