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Your body already produces many of these peptides naturally as you age, or deal with chronic inflammation, injury, or a slower metabolism, that natural production can decline

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Germ-free mice (lacking microbiota) show defects in microglial development and an exaggerated neuroinflammatory response, which can be normalized by reintroducing SCFA-producing bacteria [13]

For the kidneys, this means improved filtration efficiency, reduced scarring, and enhanced regenerative capacity, offering hope for managing conditions like chronic kidney disease and mitigating age-related organ decline (6)