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This means the FDA does not review these drugs to evaluate their safety, effectiveness, or quality before they are marketed." (Source: FDA "Compounding and the FDA: Questions and Answers".) Clinical efficacy data including the STEP 1 trial's 14.9% mean weight loss and SURMOUNT-1's 22.5% at 15mg comes from studies of the FDA-approved products, not from compounded versions

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This metabolic imbalance makes it easier to gain weight and significantly harder to lose it, even with lifestyle changes like diet and exercise

Its also important to know why this happens

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