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We then calculated the rate of glucose metabolism within 070 min in both groups of mice

Possible pathways that could alter anxiety or mood include: Effects on neurotransmitters such as dopamine and serotonin that shape motivation and pleasure Changes to gut-brain signaling that alter satiety and reward Shifts in systemic inflammation that can modulate mood circuits Improved glycemic control that reduces glucose swings known to trigger irritability or nervousness Each pathway offers a plausible biological link, though none yet proves a direct, consistent anxiolytic or depressogenic drug effect

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Moreover, increased ALDH1 high cancer cell population was observed in the xenografted tumors formed by MDA-MB 436 cells (ER36 + /ER66 ) after treatment with E2 or tamoxifen (Figure 5C)