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Finally, tablets were enteric coated with Eudragit polymer suspension (Evonik, Darmstadt, Germany) to achieve a 12.5% weight gain using a Vector LDCS3 pan coater (Freund-Vector, Marion, IA, USA)

Lastly, diabetic patients have a high prorenin levels that could contribute more significantly than renin to the pathogenesis of end-organ damage by stimulating PRR intracellular signaling ( Also at kidney level, RAS compartmentalization and independent regulation have been shown to play an important role in the pathogenesis of hypertension and diabetic nephropathy ( + balance at normal renal perfusion pressures together with promoting glomerular, tubular and interstitial inflammation and fibrosis