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The first half of 2025 has confirmed a seismic shift in the pharmaceutical landscape: GLP-1 receptor agonists a class of new drug therapies for diabetes and obesity now dominate global sales charts

Whilst retatrutide's glucose-dependent mechanism reduces the theoretical risk of hypoglycaemia when used alone, the risk can increase particularly when it is combined with insulin or sulphonylureas and dose reduction of those medicines may be needed

Circulation 124 , 19962019 (2011)

Rev Endocr Metab Disord (2021)

Because retatrutide has not received regulatory approval in the UK, there are no officially sanctioned dosage guidelines from NICE, the MHRA, or any equivalent body