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Nat Rev Dis Primers (2016) 2:16065
These include: Increased appetite and food cravings , which may work against Wegovy's appetite-suppressing effects Insulin resistance and elevated blood glucose levels , potentially leading to steroid-induced diabetes Fluid retention and weight gain , particularly in the face, neck, and trunk (cushingoid features) Redistribution of body fat to central areas Muscle wasting , which can reduce metabolic rate Patients taking both medications may experience reduced weight loss efficacy compared to those taking Wegovy alone, though the appetite-suppressing effects of Wegovy may help mitigate steroid-induced hunger
In conclusion, while a possible link between semaglutide and appendicitis exists, the evidence is not conclusive
Animal studies using the gold-standard euglycemic clamp technique confirmed that even chronic AOD-9604 treatment produced no adverse effects on insulin sensitivity, despite significant fat loss occurring
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