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Acknowledgements We would like to thank Jatinder Dhillon and the MedImmune Biologics Expression and Early Expression and Supply teams for generating the peptide-antibody fusions, Sarah Will and Arthur Suckow (MedImmune LLC, Gaithersburg, MD, USA), Dominic Corkill (MedImmune Ltd, Cambridge, UK), Michael Feigh (Gubra, Horsholm, Denmark), the MedImmune and AstraZeneca in vivo science teams for assistance in the design and conduct of rodent studies, Joerg Bluemel (MedImmune LLC, Gaithersburg, MD, USA) for supervising the non-human primate study as well as Nicholas Bhagroo (MedImmune LLC, Gaithersburg, MD, USA) for performing the in vitro glucose-stimulated insulin secretion assay
McAdam-Marx C, Mukherjee J, Bellows BK, et al
It has been suggested that the first step in blocking mitochondria trafficking along the axon is carried out by the Ca 2+ -dependent release of mitochondria from microtubules involving the combined actions of the key adaptors of kinesins and dyneins, Miro/Milton, and syntaphilin (SNPH) [46, 47]
10.1056/NEJMoa066254 93 SkibickaK
Financial Considerations: Three-month protocols provide the most accessible entry point for injectable glutathione therapy, allowing individuals to assess benefits without committing to extended programs
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