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How MOTS-c Works MOTS-c is fundamentally different from most peptides

When exposed to bile acids, ME-3 survived for 24 hours without significant loss of live bacteria. Thus, Lactobacillus fermentum ME-3 can tolerate exposure to harsh acidity in the stomach as well as exposure to bile acids in the small intestine

The strongest human clinical evidence is for topical use, including the Leyden 2002 photoaging trial and a 2023 NEEL gel topical study reporting an average 28% increase in skin collagen density at 3 months

One reported effect of milk thistle is that it can boost breast milk production in lactating mothers

It can be a little unpleasant, but it is over within less than a minute