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Yes, paracetamol is generally the safer first-line choice for pain relief whilst taking Wegovy because it does not irritate the stomach lining or carry the gastrointestinal risks associated with NSAIDs like ibuprofen, making it particularly suitable when experiencing Wegovy-related nausea or gastrointestinal sensitivity

Tirzepatide Side Effects Incidence According to a meta-analysis that pooled data from ten tirzepatide trials and over 6800 participants, 15mg/weekly tirzepatide was associated with a 10% discontinuation rate due to adverse events

doi:10.1136/bmj-2025-085304 45.Lillys Foundayo and lower-dose Zepbound helped people maintain weight loss after switching from higher doses of injectable incretin therapy in two late-phase trials