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Statistical analysis The R v4.3.3 [45] package lme4 [46] was used to carry out the linear mixed model (LMM) with treatment (or test variable) as fixed effect and block as random effect, thanks to which phenotypical and -diversity data were analysed

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According to reports, curcumin is a P450 inhibitor that inhibits CYP2C9, CYP1A2, CYP2D6, CYP2B6 and CYP3A4, with particularly low IC50 values for CYP2C9 (Sasaki et al., 2017)