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GLP-1 hormon se prirodno lui u crevima nakon obroka i ima nekoliko kljunih funkcija: smanjuje apetit usporava pranjenje eluca poveava oseaj sitosti pomae luenje insulina regulie nivo glukoze u krvi Kod osoba sa gojaznou i insulinskom rezistencijom, ovaj sistem esto ne funkcionie optimalno, pa dolazi do poveanog unosa hrane i lakeg dobijanja na teini
Seven cardiovascular outcomes trials have been performed in the past 4 years, all of which found non-inferiority for cardiovascular outcomes, with many finding superiority of these drugs
Injectable treatments are administered via a small weekly injection and are typically more potent and longer-acting
Mazdutide, targeting GLP-1 and glucagon (but not GIP), reaches about 14-20% weight loss depending on dose and trial duration
Advanced workflows using high-resolution mass spectrometry and optimized fragmentation techniques significantly improve accuracy
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