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For example, in a study where obese volunteers had unlimited access ( ad libitum ) to three meals (lunch, dinner and snacks), it was observed that treatment with semaglutide (1 mg/wk) caused a 24% decrease in energy intake during the day, leading to a reduction in body weight of approximately 5 kg after 12 weeks of treatment

Because the satiety-signaling mechanism is highly dose-dependent at the upper end of the titration schedule, Wegovy users should especially prioritize the abdomen as their default site to ensure they are getting the full benefit of their prescribed dose

[9] [10] For patients with established cardiovascular disease, SGLT2 inhibitors are generally prioritised for cardiorenal protection, with GLP-1 receptor agonists with proven cardiovascular benefit considered when SGLT2 inhibitors are unsuitable

Both peptides are generally well tolerated

This ensures the medication enters the muscle rather than subcutaneous tissue