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If you are approaching the end of the first month and still not feeling any appetite changes, our guide on 4 weeks on semaglutide with no weight loss covers the troubleshooting steps
During the first 2 to 4 weeks, you may experience: Nausea : Often most pronounced after meals, typically improving over time Reduced appetite : You may feel full more quickly and have less interest in food Mild abdominal discomfort : Bloating or a feeling of fullness Altered bowel habits : Either constipation or loose stools Fatigue : Some patients report tiredness as their body adjusts These effects are generally mild to moderate and tend to diminish as your body adapts to the medication
Critically, these considerations are offered as provisional clinical guidance only, not as formal recommendations, and must be individualized based on patient factors, drug availability, and regional regulatory status
The authors conclude that GLP-1 agonists may have little or no effect on the risk of obesity-related cancers
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