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Results in patients with diastolic blood pressure averaging 90 through 114 mm Hg
Higher investigational doses (25mg and 50mg) in the PIONEER PLUS trial showed weight reductions of approximately 10% body weight, approaching levels seen with injectable weight-loss medications
The clinical evidence demonstrates that dual agonism can achieve therapeutic outcomes that substantially exceed those of single-pathway approaches, challenging fundamental assumptions about optimal treatment strategies for diabetes and obesity
The 2023 ASA guidance recommended holding daily GLP-1 drugs on the day of surgery and weekly drugs for one week
Only statistically significant results are presented in the main text, while non-significant findings are reported in Supplementary information
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