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Macrophage activation is central to PNI pathogenesis, transitioning from a proinflammatory (M1) to an anti-inflammatory (M2) phenotype with distinct functions in inflammation and repair

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In a study of two psoriasis patients with diabetes, liraglutide therapy for 6 weeks resulted in rapid clinical improvement, characterized by increased circulating i NKT cells and they also demonstrated in vitro that GLP-1 induced a dose-dependent reduction of cytokine secretion from i NKT cells [77]

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doi: 10.1002/oby.24328, 17