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Although originally developed for the treatment of metabolic diseases, GLP-1-based therapies are now recognized for their influence on the same brain systems mediating drug-seeking and reward, suggesting therapeutic potential beyond glycemic control
It influences upstream biological conditions that regulate natural GLP-1 secretion: SCFA-mediated receptor activation (FFAR2/3) Mucosal barrier stability Reduced inflammatory tone Improved enteroendocrine cell signaling GLP-1 is a hormone
After about 46 half-lives, the circulating drug level becomes very low, meaning most of the parent peptide has been cleared from systemic circulation
Turkler C, Onat T, Yildirim E, Kaplan S, Yazici GN, Mammadov R
McCall McPhereson: Yeah, no
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