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The ENDO 2026 study presented by Sainikhil Sontha of Boston University School of Public Health, analyzing Komodo Health data covering millions of GLP-1 users with type 2 diabetes, found that the majority of those who discontinue GLP-1 medications eventually restart, primarily due to weight regain and worsening metabolic markers

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The popularity is driving prescribing outside of the subsidised indications, 14 shortages in supply, 7, 15, 16 and disruptions to therapy for people with T2D and obesity alike