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Dual-agonist incretin peptides from fish with potential for obesity-related type 2 diabetes therapy A review

For GLP-1, the review confirmed insulinotropic effects on -cells during hyperglycaemia, glucagonostatic effects on -cells during hyperglycaemia (indirect, via somatostatin and insulin), gastric emptying delay, CNS appetite suppression, and indirect promotion of lipolysis via increased sympathetic activity

Moreover, efficacy and long-term safety of either form have not been examined systematically

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In the United States, it is estimated that 100,000 people are affected by SCD and one in 500 African American babies are born with this condition (Pleasants, 2014)