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Applying a cool compress after injection may reduce mild swelling or discomfort, though avoid applying ice directly to skin

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PMID: 27191349

GLP-1 RAs under development for NASH Semaglutide Semaglutide showed a significant dose-dependent NASH resolution without worsening of fibrosis in a phase 2 randomized controlled trial (RCT) involving patients with NASH and stage 13 fibrosis

It is noteworthy that a behavioral analysis of Glp1r +/+ , Glp1r +/ and Glp1r/ mouse phenotypes and hippocampal Glp1r gene transfer demonstrated that deficiency of this receptor results in decrements in the acquisition of associative contextual learning which can be improved by hippocampal Glp1r somatic cell gene transfer [45]