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(2005) in a randomized double-blind clinical study found that a 0.001% Pal-KTTKS formulation significantly reduced wrinkle depth and volume compared to vehicle control after 8 weeks of application
Yogo I (1969)
The condition often progresses gradually, making early detection challenging without proper testing
Reported safety signals are mild in rodent studies, with no liver, heart, or dependence problems observed
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