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Central nervous system mediation occurs through GLP-1 receptors in the hypothalamus and brainstem, particularly the area postrema and nucleus tractus solitarius [8]

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In August 2023, the phase 3 Semaglutide Effects on Heart Disease and Stroke in Patients with Overweight or Obesity (SELECT) trial revealed that a 2.4-mg injection of semaglutide could reduce the risk for major adverse cardiovascular eventscomprising cardiovascular death, nonfatal myocardial infarction, or nonfatal strokeby 20% compared with placebo in adults who are overweight or obese (1)

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