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Formed through non-enzymatic glycation of proteins, lipids, and nucleic acids under chronic hyperglycemia, AGEs accumulate in the retina, cross-linking extracellular matrix (ECM) proteins and activating the receptor for AGEs (RAGE)
Lipid peroxides are formed when lipids (such as those in cell membranes) are subject to oxidative damage from ROS and other free radicals
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The resulting competition for micronutrients constitutes a critical aspect of hostpathogen interactions
PMID: 37477848
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