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November 14, 2023.

The American College of Rheumatology guidelines emphasize weight loss as a core non-pharmacological intervention for overweight and obese patients with knee osteoarthritis, with evidence supporting that even modest weight reduction (5-10% of body weight) can produce clinically meaningful improvements in pain and function

Acknowledgements We acknowledge the use of cryo-EM facilities at the Advanced Center for Electron Microscopy, Shanghai Institute of Materia Medica, Chinese Academy of Sciences

And that may be the most disruptive force of all

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