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moreover, when added to insulin therapy, the risk of these complications was significantly lower, most probably due to decreased insulin doses (39, 43)

Valproate-induced hyperammonemic encephalopathy: an update on risk factors, clinical correlates and management

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However, these drugs require subcutaneous administration, which may limit their early use

MC1R activation on melanocytes upregulates tyrosinase and downstream melanin-biosynthesis enzymes, which is why Melanotan II is a standard tool compound in melanogenesis and pigmentation research