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Comprehensive lifestyle modification programs incorporating dietary counseling, structured physical activity, and behavioral therapy can achieve clinically meaningful weight loss

DEPs were mainly located in nuclear (34.72% in Sema/HFD, 38.19% in total)

Prevalence of chronic fatigue syndrome and chronic fatigue within families of CFS patients

Circulating ghrelin levels are typically lower than expected for the degree of adiposity [17], whereas LEAP2 concentrations remain relatively unchanged or may even be elevated [27, 31], a profile that results in a reduced ghrelin/LEAP2 ratio (Table 1)