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Always inject exactly as prescribed by your PlexusDx provider on a once-weekly schedule

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Semaglutide is contraindicated in individuals with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2 due to preclinical findings of C-cell tumors in rodents[13]

If a patient has already been on a higher dose of semaglutide, I may start tirzepatide at a slightly higher dose, as their body is already accustomed to medications in the incretin class and is therefore less likely to experience adverse effects

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