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Affinity pull-down and mass spectrometric (MS) analyses consistently identified MTP (also known as HADHA) as the main interacting binding partner for GLP-1(2836)
Diabetes, Obesity and Metabolism , 2019
Both medications are typically administered as once-weekly injections, providing convenience and ease for our patients
Summary: You can eat sweets whilst taking Wegovy, as there is no absolute contraindication, but high sugar intake may reduce treatment effectiveness and worsen gastrointestinal side effects
Validation experiment based on parallel reaction monitoring (PRM) To further validate our proteomics data, we selected proteins related to lipid synthesis (Cd36, Fabp2, Fabp4, Plin2, Plin4, and Plin5), fatty acid oxidation (FAO) (Cpt1a, Acaa1b, and Cyp4a10), the mitophagy-lysosome pathway (Bnip3, Sqstm1, Optn, Map1lc3b, Lamp1, Lamp2, and Atp6v0d1), cholesterol metabolism (Abdg5, Abcg8, Cyp7a1, and Hnf4a), and the oxidative stress response (Gstm2, Hmox1, and Hspb1) for targeted proteomics analysis
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