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Mitochondrial GSH transport (via SLC25A39) and the Nrf2-ARE regulatory pathway constitute key regulatory mechanisms at the tissue/cellular level, ensuring that GSH metabolism adapts to different physiological and pathological states

Treatment of HepG2 cells with different concentrations of NFT or DEM for 24 h led to a concentration-dependent increase in Nrf2 and GCLC protein levels, whereas no significant change was observed in the levels of the modifier subunit, GCLM (Fig

2017, 35, 21412148 DOI: 10.1200/JCO.2016.70.8297 vc-PABC-EDA-seco-DUBA ADC (duocarmazine) Mol

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3a) and GGT activity (Fig