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Similar to other lcFAODs, muscular symptoms are more prominent in adulthood or adolescence and liver-related signs and symptoms are generally seen in early childhood, but patients can present with both in different stages of life

Cravings and hunger naturally decrease, making lifestyle changes more manageable

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Gut microbiota dysbiosis and metabolites (e.g., histamine, SCFAs) modulate visceral sensitivity and low-grade inflammation, affecting bowel motility, sensitivity and secretion

Most studies on the role of mitochondria in synaptic transmission have focused on the organelles presynaptic pool