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They enhance autophagy and reduce lipotoxicity-induced hepatocyte apoptosis, thereby preserving the integrity of liver parenchyma ( action to enhance anti-fibrotic efficacy ( In summary, GLP-1 receptor agonists exert anti-fibrotic effects in MASLD through the inhibition of hepatic stellate cell activation, the modulation of profibrotic signaling pathways, and the promotion of hepatocyte regeneration
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Safety signals: FDA's significant-risk list cites serious adverse events associated with CJC-1295, including increased heart rate and systemic vasodilatory reaction
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