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Collectively, the gut microbiota acts as a critical nexus linking PCOS-related metabolic disturbances to reproductive dysfunction through its metabolites, immune interactions, and neuroendocrine networks

While glutathione and NAD+ are buzzy right now, experts say other ingredients are ripe for topical innovation, including highly concentrated and optimized forms of vitamin C and peptides

However, significant challenges remain, including the synthesis of stable tripeptides with good tissue penetration, insufficient understanding of their mechanisms of action, the scarcity of studies in larger animal models and human trials, and the lack of direct head-to-head comparisons with larger peptides [75, 95]

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doi: 10.1016/j.orcp.2019.07.001 26