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Call 999 or go to your nearest A&E immediately if you experience: Signs of a serious allergic reaction (anaphylaxis) , including facial or throat swelling, difficulty breathing, a rapid heartbeat, or a widespread rash this is a medical emergency Severe difficulty breathing or collapse Contact your GP, NHS 111, or your trial medical team promptly if you experience: Persistent or severe vomiting or diarrhoea that prevents adequate fluid or food intake

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