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In NOX4 knockout mice, cysteine helped protect the liver from acetaminophen injury.[ref] Vitamin B6, pyroxidine: Vitamin B6 is an essential cofactor in the transulfuration pathway with the CBS enzyme, which converts homocysteine to cysteine (and then to glutathione)

Similarly, a roGFP2-iL-Grx1 fusion redox probe targeted to the ER of Arabidopsis thaliana cells lacking Ero1/2, the functional homolog of DsbB in eukaryotes was more reduced, and re-oxidation after a reductive pulse was inhibited by the lack of Ero1/2 (Ugalde et al., 2022)

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