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Nutrients, 12 (4), 1112
As part of the incretin system, GLP-1 helps stabilize post-meal glucose levels by enhancing insulin secretion, suppressing glucagon release, slowing gastric emptying, and increasing feelings of satiety (5)
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semaglutide should be discontinued at least two months before a planned pregnancy During treatment , patients should: Attend all scheduled follow-up appointments to monitor both metabolic parameters and general wellbeing Keep a symptom diary noting any mood changes, particularly in the first three months of treatment Maintain open communication with healthcare providers about any concerns, however minor they may seem Continue existing mental health treatments unless specifically advised otherwise by a psychiatrist Adopt healthy lifestyle measures including regular physical activity, adequate sleep, and balanced nutrition, which support both metabolic and mental health Be aware that hypoglycaemia risk increases when GLP-1 agonists are used with insulin or sulfonylureas, and dose adjustments of these medications may be needed Common adverse effects of GLP-1 agonists include nausea, vomiting, diarrhoea, and constipation, which typically improve over time
For patients with type 2 diabetes or prediabetes, this dual benefit of weight loss and glycemic control is particularly advantageous
