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SIRT1 function is also modulated through protein-protein interactions: DBC1 inhibits SIRT1 activity via complex formation, 30,49 whereas AROS and SENP1 interact with SIRT1 to enhance its activity, expanding the spectrum of functional regulation

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Tesamorelin also supports muscle preservation through GH and IGF-1 elevation, potentially counteracting the lean mass loss associated with aggressive weight loss peptide protocols

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