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2 Mechanisms of action and ongoing therapeutic innovations in GLP-1 receptor agonists All GLP-1 RAs mimic the endogenous hormone GLP-1, binding to GLP-1 receptors (GLP-1 Rs) distributed in pancreatic islets, the gastrointestinal tract, and the brain

BMI thresholds still exist because clinical trials primarily studied patients meeting specific BMI requirements, and FDA indications and insurance policies are generally based on those populations

Currently, less than 2% of individuals with obesity in the U.S

Etiological Considerations Mycotoxin exposure was suspected based on environmental timing and symptom pattern