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In mouse models of NASH, GLP-/GIP dual agonists have also been found to significantly reduce TG and LDL-C and increase high-density lipoprotein cholesterol (HDL-C) [127]

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The hormone stimulates red blood cell production, which improves oxygen delivery but can thicken blood excessively

Double incretin receptor knockout (DIRKO) mice 39 , and glucagon-like peptide double receptor knockout (GLPRDKO) mice were generously provided by Dr