Subclinical deficiency common in people who drink alcohol, eat refined carbohydrates regularly, or take metformin produces fatigue, brain fog, and cognitive sluggishness that is almost instantly reversible with B1 repletion
Lim K, Lu TS, Molostvov G, Lee C, Lam FT, Zehnder D, Hsiao LL
Levels decline with age, and supplementation may enhance mitochondrial function, improve energy metabolism and promote healthy aging
It also performs a dual action that distinguishes it from simple collagen-boosting ingredients: it upregulates the matrix metalloproteinases (MMP-1 and MMP-2) that clear damaged collagen, while simultaneously upregulating tissue inhibitors (TIMP-1) that prevent excessive degradation [3]
Indeed NSAIDs, by virtue of their renown anti-inflammatory and antiplatelet (especially aspirin) activities could be beneficial for both the early control of inflammation and the prevention of thromboembolism, thus theoretically limiting COVID-19 progression in a bimodal pattern
