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N-acetyl-cysteine (NAC) reduces the concentrations of NADPH and L-arginine (the precursor of peroxides) in the renal cortex 348 , reducing the possibility of ferroptosis in renal cells

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For example, daily oscillations of commensals such as Parabacteroides distasonis modulate the cyclical pattern of arthritic inflammation,Citation 18 whereas resynchronization of rhythmic taxa including Lactobacillus and Lachnoclostridium is linked to improvements in non-alcoholic fatty liver disease.Citation 19 Conversely, environmental stressors such as HFD feeding markedly disrupt microbial oscillations, causing loss of rhythmicity in inflammation-associated taxa and fostering arrhythmic, low-grade inflammation characterized by elevated pro-inflammatory cytokines and impaired barrier integrity.Citation 20 Collectively, these findings establish the gut microbiota as a central mediator translating dietary and temporal cues into host inflammatory responses