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Conclusion The future of GLP-1 RAs is promising, with expanding indications and ongoing trials that could transform the management of metabolic, liver, neurodegenerative, and CVDs

No significant incidence of graft rejection was observed

In arthrofibrosis, osteoarthritis and rheumatoid arthritis, fibrosis of the synovial lining (lining around joints) can occur, creating inflammation, pain and restricted joint mobility [1,7]

Graphical abstract Access this article Similar content being viewed by others Data availability Data that support the findings of this study are available by the Lombardy Region, but restrictions apply to the availability of these data and codes, which were used under license for the current study, and so they are not publicly available

Thus the actions of GLP-1 on the insulin gene promoter appear to be mediated by both PKA-dependent and -independent mechanisms, the latter possibly involving the mitogen-activated protein kinase pathway (146)