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In the mouse EWcp, immunofluorescence targeting UCN1 and CART peptides were performed to assess neuronal activation as well as UCN1 and CART peptides content

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Notably, Arg1 expression in MDSCs contributes to arginine depletion in the microenvironment, further inhibiting T-cell antitumor function and reducing their survival

These improvements occur alongside increased serum carnitine levels and reduced markers of oxidative stress, suggesting comprehensive cellular rejuvenation rather than isolated symptomatic benefits