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Notably, the FDA does not review or test compounded drugs

Pregnancy and breastfeeding are contraindications for phentermine, and berberine should also be avoided during these periods due to insufficient safety data

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These drugs also slow down gastric emptying, which helps you feel fuller for longer.12 They also act on your brain chemistry to influence feelings of satiety, reducing the potential for a hormonal imbalance signaling that youre hungry when you arent.13 These various mechanisms of action work together to create a situation that makes it easier to lose weight by reducing your caloric intake and improving your insulin response