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Others are located in the dorsal raphe nucleus, which produces nearly all of the serotonin used by the forebrainthe same neurotransmitter system targeted by selective serotonin reuptake inhibitors

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Patients should be counselled about this possibility and reassured that symptoms typically improve

A phase 2 dose-finding trial in subjects with type 2 diabetes showed clear dose-dependent effects on HbA1c and weight over 12 weeks of treatment

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