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A 12-week randomized trial demonstrated: Average weight loss of 2.6 kg in AOD-9604 group (1 mg/day) versus 0.8 kg in placebo group Preferential reduction in abdominal and visceral fat deposits No adverse effects on carbohydrate metabolism or insulin sensitivity Non-dose-dependent effects, with higher doses (10 mg/day) producing less weight loss than lower doses However, a subsequent 24-week Phase III trial with 502 subjects incorporating intensive diet and exercise showed no statistically significant weight loss compared to placebo, leading to development termination in 2007

R.20074052 EOF68 EOF 77

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MT-1 is produced via solid-phase peptide synthesis (SPPS), a precisely controlled chemical method that ensures accurate replication of the 13-amino acid sequence while preserving the two critical structural modifications

Internal Medicine Review 3 (2017): Issue 4