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Mild gastrointestinal discomfort such as nausea or stomach upset may occur

1 GLP-1Rs are found on a variety of cells including those of the endocrine pancreas, keratinocytes, endothelial cells, neurons, astrocytes, microglia, pancreatic beta-cells, intraepithelial lymphocytes, neutrophils, and eosinophils

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Whether oral BPC-157 produces significant systemic effects beyond the GI tract through mucosal absorption remains an area of active research: some preclinical studies suggest systemic effects at higher doses, but the primary clinical rationale for oral administration is local gut action